diff --git a/config-unix.mk b/config-unix.mk
index da7df03c..74db9492 100644
--- a/config-unix.mk
+++ b/config-unix.mk
@@ -51,7 +51,7 @@ endif
 ifeq (Darwin,$(uname_S))
 EV_CONFIG=config_darwin.h
 EIO_CONFIG=config_darwin.h
-CPPFLAGS += -Isrc/ares/config_darwin
+CPPFLAGS += -D_DARWIN_USE_64_BIT_INODE=1 -Isrc/ares/config_darwin
 LINKFLAGS+=-framework CoreServices
 OBJS += src/unix/darwin.o
 OBJS += src/unix/kqueue.o
diff --git a/uv.gyp b/uv.gyp
index c09c2e5d..d9e3f3c4 100644
--- a/uv.gyp
+++ b/uv.gyp
@@ -215,6 +215,7 @@
             ],
           },
           'defines': [
+            '_DARWIN_USE_64_BIT_INODE=1',
             'EV_CONFIG_H="config_darwin.h"',
             'EIO_CONFIG_H="config_darwin.h"',
           ]