diff --git a/CMake/CurlTests.c b/CMake/CurlTests.c
index 3fc3c86ba8..03346187d6 100644
--- a/CMake/CurlTests.c
+++ b/CMake/CurlTests.c
@@ -166,9 +166,6 @@ int main(void) { return 0; }
 #ifdef HAVE_IOCTLSOCKET
 /* includes start */
 #ifdef _WIN32
-#  ifndef WIN32_LEAN_AND_MEAN
-#    define WIN32_LEAN_AND_MEAN
-#  endif
 #  include <winsock2.h>
 #endif
 int main(void)
@@ -185,9 +182,6 @@ int main(void)
 #ifdef HAVE_IOCTLSOCKET_CAMEL
 /* includes start */
 #ifdef _WIN32
-#  ifndef WIN32_LEAN_AND_MEAN
-#    define WIN32_LEAN_AND_MEAN
-#  endif
 #  include <winsock2.h>
 #endif
 int main(void)
@@ -203,9 +197,6 @@ int main(void)
 #ifdef HAVE_IOCTLSOCKET_CAMEL_FIONBIO
 /* includes start */
 #ifdef _WIN32
-#  ifndef WIN32_LEAN_AND_MEAN
-#    define WIN32_LEAN_AND_MEAN
-#  endif
 #  include <winsock2.h>
 #endif
 int main(void)
@@ -222,9 +213,6 @@ int main(void)
 #ifdef HAVE_IOCTLSOCKET_FIONBIO
 /* includes start */
 #ifdef _WIN32
-#  ifndef WIN32_LEAN_AND_MEAN
-#    define WIN32_LEAN_AND_MEAN
-#  endif
 #  include <winsock2.h>
 #endif
 int main(void)
@@ -297,9 +285,6 @@ int main(void)
 #ifdef HAVE_SETSOCKOPT_SO_NONBLOCK
 /* includes start */
 #ifdef _WIN32
-#  ifndef WIN32_LEAN_AND_MEAN
-#    define WIN32_LEAN_AND_MEAN
-#  endif
 #  include <winsock2.h>
 #endif
 /* includes start */
@@ -410,9 +395,6 @@ int main(void)
 #ifdef HAVE_WIN32_WINNT
 /* includes start */
 #ifdef _WIN32
-#  ifndef WIN32_LEAN_AND_MEAN
-#    define WIN32_LEAN_AND_MEAN
-#  endif
 #  ifndef NOGDI
 #    define NOGDI
 #  endif
diff --git a/CMake/OtherTests.cmake b/CMake/OtherTests.cmake
index f6ba407f69..736d539c87 100644
--- a/CMake/OtherTests.cmake
+++ b/CMake/OtherTests.cmake
@@ -39,7 +39,6 @@ if(NOT DEFINED HAVE_STRUCT_SOCKADDR_STORAGE)
   unset(CMAKE_EXTRA_INCLUDE_FILES)
   if(WIN32)
     set(CMAKE_EXTRA_INCLUDE_FILES "winsock2.h")
-    set(CMAKE_REQUIRED_DEFINITIONS "-DWIN32_LEAN_AND_MEAN")
     set(CMAKE_REQUIRED_LIBRARIES "ws2_32")
   elseif(HAVE_SYS_SOCKET_H)
     set(CMAKE_EXTRA_INCLUDE_FILES "sys/socket.h")
diff --git a/CMakeLists.txt b/CMakeLists.txt
index 515e3ba88c..80fa668c04 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -165,6 +165,8 @@ if(WIN32)
     endif()
   endif()
 
+  list(APPEND CMAKE_REQUIRED_DEFINITIONS "-DWIN32_LEAN_AND_MEAN")  # Apply to all feature checks
+
   set(CURL_TARGET_WINDOWS_VERSION "" CACHE STRING "Minimum target Windows version as hex string")
   if(CURL_TARGET_WINDOWS_VERSION)
     add_definitions("-D_WIN32_WINNT=${CURL_TARGET_WINDOWS_VERSION}")