diff --git a/CMakeLists.txt b/CMakeLists.txt
index f1de3843a0..e6d0e5190e 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -144,6 +144,16 @@ if(ENABLE_CURLDEBUG)
   set_property(DIRECTORY APPEND PROPERTY COMPILE_DEFINITIONS CURLDEBUG)
 endif()
 
+# This combination results in curl tool crashing on startup when run on native
+# Windows (it was seen to work when run under WINE though). We disable UNITY
+# mode as a workaround.
+if(ENABLE_UNICODE AND ENABLE_CURLDEBUG)
+  set(CMAKE_UNITY_BUILD OFF)
+  message(WARNING "Unity builds are not supported with Windows Unicode and "
+    "TrackMemory (-DCURLDEBUG) enabled at the same time. Unity mode has been "
+    "disabled.")
+endif()
+
 # For debug libs and exes, add "-d" postfix
 if(NOT DEFINED CMAKE_DEBUG_POSTFIX)
   set(CMAKE_DEBUG_POSTFIX "-d")