diff --git a/lib/vtls/openssl.c b/lib/vtls/openssl.c
index 43c9dd395c..924cd1c7e2 100644
--- a/lib/vtls/openssl.c
+++ b/lib/vtls/openssl.c
@@ -203,11 +203,13 @@
 /* Whether SSL_CTX_set_ciphersuites is available.
  * OpenSSL: supported since 1.1.1 (commit a53b5be6a05)
  * BoringSSL: no
- * LibreSSL: no
+ * LibreSSL: supported since 3.4.1 (released 2021-10-14)
  */
-#if ((OPENSSL_VERSION_NUMBER >= 0x10101000L) && \
-     !defined(LIBRESSL_VERSION_NUMBER) &&       \
-     !defined(OPENSSL_IS_BORINGSSL))
+#if ((OPENSSL_VERSION_NUMBER >= 0x10101000L && \
+      !defined(LIBRESSL_VERSION_NUMBER)) || \
+     (defined(LIBRESSL_VERSION_NUMBER) && \
+      LIBRESSL_VERSION_NUMBER >= 0x3040100fL)) && \
+    !defined(OPENSSL_IS_BORINGSSL)
   #define HAVE_SSL_CTX_SET_CIPHERSUITES
   #if !defined(OPENSSL_IS_AWSLC)
     #define HAVE_SSL_CTX_SET_POST_HANDSHAKE_AUTH