diff --git a/lib/vquic/curl_msh3.c b/lib/vquic/curl_msh3.c
index 1a5692305a..bdc2ecb000 100644
--- a/lib/vquic/curl_msh3.c
+++ b/lib/vquic/curl_msh3.c
@@ -46,6 +46,10 @@
 #include "curl_memory.h"
 #include "memdebug.h"
 
+#ifdef CURL_DISABLE_SOCKETPAIR
+#error "MSH3 cannot be build with CURL_DISABLE_SOCKETPAIR set"
+#endif
+
 #define H3_STREAM_WINDOW_SIZE (128 * 1024)
 #define H3_STREAM_CHUNK_SIZE   (16 * 1024)
 #define H3_STREAM_RECV_CHUNKS \